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Further, inhibition of AKT signaling molecule, which has been shown to be crucial in regulating physiologic platelet formation, significantly reduced the number of collected platelets, suggesting the applicability of this tissue model for evaluation of the effects of bone marrow exposure to compounds that may affect platelet formation.
These may affect platelet and vascular function.
In theory, alcohol may affect platelet function, coagulation physiology, and enhance vascular fragility [ 23].
Autoantibodies reacting with glycoprotein (GP IIb/IIIa may affect platelet aggregation; these are the most common autoantibodies seen in primary ITP [ 10].
Exclusion criteria were as follows: (1) lack of pretreatment platelet count records (n = 12) and (2) concomitant diseases that may affect platelet count, such as autoimmune disease, history of blood transfusion, liver cirrhosis, and severe hypertension (n = 31).
Exclusion criteria included patients who had taken any medications within the preceding two weeks that may affect platelet function, such as aspirin, other nonsteroidal inflammatory drugs, thienopyridines, glycoprotein IIb/IIIa receptor antagonists, dipyridamole, and penicillins [ 21].
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Also, as we know, patients with advanced-stage NPC often require chemoradiotherapy, and chemotherapy may inhibit marrow function and affect platelet count before radiotherapy.
Ginkgo extract has been suggested to affect platelet aggregation, which may not only be useful in prevention of pathological events as thrombosis, but may also cause spontaneous bleeding in healthy individuals or patients treated with anticoagulants such as warfarin and aspirin [ 83].
It is well known that chronic infections affect platelet counting directly [ 18, 19] and HCV infection may lead to hemorrhagic problems [ 29].
These GO groups may contain toxin-like transcripts similar to synergistic components of snake venom which induce blood coagulation and affect platelet function [ 76].
Could stent design affect platelet activation?
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