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Lange et al. [24] suggest that CRP may affect plaque rupture rather than atherosclerosis in a study reporting an association of CRP genotype with incident CHD in a subgroup but no association with CIMT in the same subgroup or in the study population as a whole.
Another possibility is that open-skull surgery induces local inflammation and gliosis in the first weeks after surgery [ 8], which may affect plaque growth [ 24].
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This conflicting pattern suggests that apoE may affect plaques and CAA deposition via a different mechanism(s).
Advanced glycation end products (AGEs) and receptors of AGEs (RAGE) may also contribute to the development of micro- and macroangiopathy in diabetes mellitus which may affect coronary plaque progression as well as vascular remodeling [ 15- 19].
These observations provide insights into the role calcification may play in the stability of the atherosclerotic plaque and suggest that it is not only the amount of vascular calcification, but the morphology, size and location that affect plaque vulnerability.
Thus, breath analysis for the detection of systemic diseases should consider plaque activity, and denitrification in dental plaque may affect the physiology of the whole human body.
These sex differences may affect the prevalence of vulnerable plaque in different tertiles in patients without DM.
Once the infection plaque was formed, two factors may affect the phage progeny's prospect of migrating out of the current plaque: (1) the size of the plaque and (2) the productivity of the plaque.
The researchers suggested that vascular risk factors may affect the metabolism of beta-amyloid plaque, which accumulates in the brains of Alzheimer's patients and seems to play a pivotal role in the disease.
In fact, a reduced production of collagen and its uncontrolled degradation may affect the stability of the vessel wall especially in atherosclerotic plaques by making them prone to aneurysm and rupture.
Thus, processes occurring in the spinal canal, including also the spinal cord, may affect the results of CSF analyses, although the occurrence of active plaques in the spinal cord was not investigated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com