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Dr. Margolis is the recent recipient of an NIEHS funded K Award to study how exposure to neurotoxic chemicals may affect neurodevelopment and manifest as subsequent learning and social problems.
Additionally, these data suggest that OPFRs may affect neurodevelopment with similar or greater potency compared to known and suspected neurotoxicants.
Thus, the disruption of endocrine pathways by prenatal exposure to hormonally active environmental chemicals may affect neurodevelopment in children.
Type 1 diabetes, or an aspect of the disease, may affect neurodevelopment such that youth with the disease show less normative age-related increase in brain volume.
It has thus been suggested that PBDEs may affect neurodevelopment and fertility by disrupting THs (Agency for Toxic Substances and Disease Registry 2004; Harley et al. 2010).
There is substantial toxicologic evidence that repeated low-level exposure to organophosphate (OP) pesticides may affect neurodevelopment and growth in developing animals.
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It is clear, however, that thyroid hormones are important regulators of brain development, and research suggests that such interferences may adversely affect neurodevelopment early in life, which in turn may have long-term neurologic consequences for individuals.
According to this hypothesis, firstborn children are exposed to fewer infections from other children early in childhood and, because of delayed immunologic challenge, may be more likely to develop autoimmune responses including those that may adversely affect neurodevelopment (29).
In summary, there are several lines of evidence that suggest that prenatal and or early life paracetamol exposure may adversely affect neurodevelopment.
Another potential mechanism is that DDT may also affect neurodevelopment by reducing the density of muscarinic cholinergic receptors involved in neuronal transmission (Eriksson et al. 1992).
Although nutritional deficiencies may negatively affect neurodevelopment, the associations observed between prenatal pesticide exposure and children's test scores were independent of stunting and other indicators of nutritional status.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com