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Reports suggest sildenafil decreases pulmonary hypertension and may affect myocardial function.
Taken together, these studies confirm the importance of ADORA1 in the pathobiology of heart diseases, but do not explain how the differential up-regulation of this receptor in adjacent adipose tissues may affect myocardial or vascular function.
To go further, we determined that mir-30d may affect myocardial pyroptosis via targeting foxo3a and its downstream protein, ARC.
Hyperglycemia in early pregnancy may affect myocardial and placental development, thus contributing to the susceptibility to hypoxia seen in these infants.
All type 2 diabetic patients in this study received oral antidiabetic therapy (see Table 1), which are known to exert cardiovascular effects and may affect myocardial blood flow.
Overall, these findings support that PM may affect myocardial ischemia, and partly through such a mechanism, PM increases cardiovascular risk, such as sudden cardiac death and myocardial infarction.
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Increased production of inflammatory cytokines may adversely affect myocardial function.
Consequently, infectious diseases, such as myocarditis, may also affect myocardial perfusion by inducing local inflammation and necrosis.
Therefore, we hypothesized that episodes of metabolic dysregulation due to insufficient insulin provision may adversely affect myocardial TG content and myocardial function.
It has been speculated that, owing to these beneficial effects, levosimendan may positively affect myocardial performance and regional hemodynamics, thereby improving microcirculatory perfusion [ 6- 12, 15, 16, 16].
Thirdly, isoflurane anesthesia is known to affect myocardial glucose uptake [29, 30] and may have influenced the results.
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may affect EPCs
may affect early
may affect individual
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