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Some of the Knops blood group polymorphisms, which are due to single nucleotide changes in the CR1 gene (Ref. 222), may affect malaria susceptibility (Refs 223, 224).
Here we argue that immune-mediated virulence, or 'immunopathology,' may affect malaria virulence evolution and should be considered in the design of medical interventions.
Figure 2 illustrates the effects of host death and each of our immune manipulations on the duration of gametocytemia, and argues that both death and host heterogeneity in the inflammatory state may affect malaria transmission potential.
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Most regions highly endemic for malaria are also endemic for other infectious diseases, which may affect the malaria infection [1].
Other factors may have also changed during the study period and may have affected malaria visits and admissions.
Many other factors can affect malaria, and some may counteract the effects of weather and climate (Confalonieri et al. 2007; Lafferty 2009).
Background: Climate change may affect Plasmodium vivax malaria transmission in a wide region including both subtropical and temperate areas.
With respect to the role of the MDAs, there is documented evidence that anopheles mosquitoes taking a blood meal on ivermectin treated individuals show increased mortality [ 38], and that MDAs for LF in this way may affect transmission of malaria [ 39].
Because previous exposure to malaria may affect the reactogenicity and immunogenicity of malaria vaccines, we conducted a Phase 1 dose escalation trial of this vaccine in malaria-experienced adults in Mali.
Drugs specifically targeting these sexual stage parasites may affect the spread of malaria in the human population.
While a few pioneering theoretical studies explored how innate immunity may affect the dynamics of malaria infections [23] [25], none of them has considered whether innate immunity can describe the early dynamics of infections with Plasmodium chabaudi.
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