It may affect one (localized) or multiple organs (systemic) and can have a family pedigree (familial).
If MAM is indeed an LR, then alterations in its structure and composition may affect profoundly the cellular functions localized within it.
Our observation that SUMOylated VHL localizes to the nucleus, while ubiquitylated VHL is cytoplasmic, suggests that posttranslational modification may affect VHL subcellular localization and its inhibitory function on HIFα.
Thus, apoE is localized where it may affect the biological expression of two characteristic AD pathological correlates: extracellular A beta deposition and intraneuronal tau metabolism and NFT formation.
By constructing strains that express phospho-mutant versions of Chs2, we determined that phosphorylation of Chs2 on S222 does not influence the measured in vitro activity of the enzyme, but instead, may affect amount of protein that is localized to specific sites of cells.
APP and Aβ reportedly localize to mitochondria, and may affect mitochondrial function, but mitochondrial function also modifies APP processing (Swerdlow, 2012).
Hydrodynamism in fact may affect sedimentation rates, larval settlement and, together with localized vertical nutrient fluxes and material retention, the productivity of the area [6], [9] [12].
The disease may be localized to a segment or may affect longer segments of bowel [ 13].
Infections can be localized in one part of the cervix, or they may affect the whole structure.
Localized scleroderma affects mainly the skin, while systemic scleroderma may affect many parts of the body.
