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Specific nutrients, like the protein and fat found in yeast, may affect lifespan more than others, she says.
We next tested whether arsenite may affect lifespan of the short-lived multicellular model organism C. elegans.
The mdl-1 mutant phenotype also suggests that this gene may affect lifespan through its effects on the germline.
Thus, an alternative mechanism supported by the proteomics data is that changes in the synthesis and breakdown of proteins (protein metabolism) may affect lifespan.
Finally, we will discuss the cellular effects of insulin signaling that may affect lifespan and discuss opportunities for pharmacological intervention highlighted by C. elegans biology.
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These data indicate that although single-gene effects may significantly affect lifespan (Friedman & Johnson, 1988a; Guarente & Kenyon, 2000), molecular stochastic processes also have to be taken into account as significant factors that limit lifespan in individual animals.
Our findings thus support the notion that intracellular PE levels may affect the lifespan through regulation of autophagy.
Since OPA1 is ubiquitously expressed and OPA1 mutation is associated with altered mitochondrial dynamics and elevated ROS production in the Drosophila retinal cells, OPA1 insufficiency may also accelerate aging and affect lifespan.
First, although alteration of one nutrient can affect lifespan, this may lead to a change in the intake or processing of other nutrients in the mixture.
However, the manner in which biogenic amine neurotransmitters affect lifespan, and how CIN may modulate that mechanism requires further investigation.
Thus, while DR and IIS clearly affect lifespan through independent targets, there may also be some prolongevity targets that are convergently regulated by these pathways.
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