Sentence examples for may affect inhibitor from inspiring English sources

Even though this mutation does not impact the Tyr477 side chain rotamer position, it may affect inhibitor binding by providing a distorted packing between the N-terminal portion and the Tyr477-residing C-terminal fragment that lines up the active site entrance.

One major concern is that there are additional, yet unidentified molecular factors that may affect PARP1 inhibitors [28].

One explanation for this difference may be the absence of either basigin or embigin when MCTs are expressed in yeast, and this might affect inhibitor binding.

Since cyclin D1 is one of STAT3 major targets and is involved in cell proliferation, we analyzed whether treatment with STAT3 inhibitor may affect cyclin D1 expression in NF861 and NF797 foci compared to NIH3T3 cells.

In AKT3, substitution of a threonine residue for serine at position 203 (equivalent to AKT1 Ser 205) may affect the ability of Inhibitor VIII to hydrogen bond to the protein and also alters the binding pocket by introducing an additional methyl group.

Dysfunction of V-ATPase induced by an inhibitor may affect intracellular homeostasis supported by an appropriate pH balance.

To further address the question of how multiple phosphorylation sites may affect a substrate-selective inhibitor we constructed a simplified model incorporating varying numbers of ATF2 and MK2 phosphorylation sites (Additional File 1 Supplementary Figure S1).

Given the findings of Saven et al., [23] it was essential to consider possible structural deviations or fluctuations in the α1β1 loop region that may affect binding of such inhibitors.

Impairment in the extrusion of signaling molecule through the application of efflux pump inhibitors may affect the process of quorum sensing or cell to cell signaling [47, 48] (Fig. 1).

Therefore, anti-ICAM-1 antibody-coated beads were used instead of leukocytes, since the inhibitors may affect the function of the leukocytes.

However, due to the limitation of co-immunoprecipitation, these inhibitors may affect dimerization which can not be revealed by co-immunoprecipitation due to the existence of at least 3 different interaction sites of the oligomeric ABCG2 [6], [6].