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In spite of high copy numbers of full-length hTERT mRNA, telomerase activity was low in some cases correlating with low copy numbers of hTR, raising the possibility that alteration of the hTR : hTERT ratio may affect functionally active telomerase activity in vivo.
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Alarcon and colleagues proposed that in TLE a lesion may affect remote, functionally coupled normal brain regions and that IED may originate from separate regions, resulting in propagation to and recruitment of other neuronal assemblies (Alarcon et al., 1997).
It is therefore possible that SYT-SSX may affect the expression of functionally related groups of genes through a general mechanism that perturbs methylation and imprinting.
In other words, in a given biological network not every component is functionally or 'socially' equivalent, and each may affect the dynamics of the network, and hence the organism, in different ways.
This may affect the reliability of detecting change over time, particularly the subtle but functionally significant changes seen in many white dot syndromes.
Although most of these sites are not structurally or functionally annotated, they are in close proximity to the DNA and may affect binding abilities and hence alter patterns of transcriptional regulation.
2 p34 has been functionally implicated in the intracellular transport of clathrin-coated vesicles, 3 and may affect cell signalling via regulation of the expression of receptor tyrosine kinases, which are turned over by clathrin- and AP2-dependant mechanisms.
Functionally, these genes may impact recombinational repair of DOX-induced lesions or alternatively, they may affect cell cycle progression (checkpoint) in G1 or early S phase.
Politics may affect the studies as well.
It also may affect things like compensation.
That may affect their play.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com