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Binding to CA-I and CA-II, which are highly concentrated in erythrocytes, may affect drug pharmacokinetics.
Potential alterations in transport routes like adsorptive mediated endocytosis and receptor-mediated endocytosis may affect drug delivery to the brain.
In vivo case reports and in vitro studies have indicated that aerosol therapy using face masks can result in drug deposition on the face and in the eyes, and that face mask design may affect drug delivery.
Obesity likely may affect drug metabolism and distribution.
Such variations may affect drug safety and efficacy.
For example, age-related changes in the gastrointestinal tract may affect drug absorption.
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These factors may affect drug-delivery property into the cell.
One important thing to infer from this is that we should be cautious about the epigenetic property of drugs, which may affect drug-metabolizing gene expression and drug disposition.
In addition to SF composition itself, the molecular weight and charge of encapsulated drugs may significantly affect drug release from SF matrices.
It would be important to identify the selection pressure at these residues since amino acid changes at these sites may dramatically affect drug binding.
43 Stress, changes in diet, endocrine changes and other drugs may also affect drug metabolism.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com