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Some doctors believe that the phosphoric acid in cola drinks is to blame, because it may affect calcium metabolism and bone mass.
High intakes of phosphorus (as phosphate) may affect calcium metabolism adversely and interfere with the absorption of trace elements such as iron, copper, and zinc.
It has been suggested that brain-derived infectious PrPRES [30] and synthetic PrP peptides may affect calcium homeostasis [46], [47], [48], [49], [50], [51], but its possible contribution to PrPRES neurotoxicity and ER stress has not been addressed directly.
It is plausible that cadmium exposure may affect calcium and zinc distribution and function in children as well.
Yet interestingly, our studies revealed two cDNAs that responded to cadmium that represent putative calcium binding proteins (singlet 97 and contig 220), suggesting that cadmium may affect calcium regulatory pathways in more subtle ways that contribute to its overall effects.
The results of the current study suggested that infant formula fat blend differences may affect calcium and fat balance and GI stool tolerance in formula fed infants receiving HM supplementations.
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14 ERs have been found in the gut and the kidney and some observations suggest that estrogen may positively affect calcium absorption, independently from other circulating calciotropic hormones.
Alternatively, PHLDA2 may indirectly affect calcium and bone metabolism through its role in regulating the placental hormones [24] involved in driving the maternal adaptations to pregnancy, which include increased maternal bone turnover.
In vitro experiments and animal models of CHB also point to a major role for anti-Ro52 antibodies in CHB pathogenesis and suggest that these antibodies may directly affect calcium regulation in the fetal heart, leading to disturbances in signal conduction or electrogenesis or both.
Three drugs that affect calcium pathways and may influence this repartitioning, i.e. dantrolene, azumolene (a water-soluble dantrolene analogue) and nimodipine, were studied in cell culture, using both a transformed follicle centre lymphoma cell line and primary culture of lymphoma cells in vitro in a manner that resulted in a growth pattern closely resembling that of the malignancy in vivo.
We conclude that alterations of pH significantly affect calcium signaling and force production in the human myometrium and may contribute to dysfunction in labor.
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