Note that some GFP/TAG1 double-positive axons in the control and NICD embryos were observed in the ventral midline (Fig. 4C, F, arrowheads in inserts), indicating forced Notch activation may not affect axon guidance toward and across the midline.
Erythropoietin-producing hepatocellular carcinoma receptors (Ephs) and their ligands Ephrins can affect axon growth.
Exploiting the spatially embedded nature of our network, we investigate how anisotropy may affect the volume requirement of axons via an altered number of axon encounters (see Figure 3).
The aim of the present study was to examine the L2 dendrite morphology which may affect the size of the L2 axon.
Finally, CNV data obtained by Morrow et al implicated CNVs within genes such as PCDH10, CNTNAP2, NLGN3, NLGN4 and NRXN1, as well as non-coding variants, such as CNVs near CNTN3, involved in axon outgrowth, which may affect transcription control regions.
However, it is important to note that such defects in innervation might arise not only from the altered responses of p75NTR-deficient neurons to neurotrophins, but because the absence of p75NTR on pathways along which axons grow towards their targets (Yan and Johnson, 1988) may affect the presentation of neurotrophins to growing axons in p75 NTR null mutant mice (Lee et al., 1994b).
Trans RET signaling may affect many cellular processes, including directional axonal outgrowth and promotion of axon regeneration (Paratcha et al., 2001; Airaksinen and Saarma, 2002; Ledda et al., 2002).
Localization of misfolded SOD1 species in motor axons of SOD1 G93A -Tg mice suggests that misfolded SOD1 species may affect the function of proteins required for axonal transport.
According to the literature [ 52], we expected that the nerve degeneration would be equal for axons of all sizes and may affect either the myelinated (type Abeta/Adelta) or the unmyelinated (type C, mostly nociceptors) fibers.
Because oligodendrocytes (OLs) are responsible for myelination of axons, abnormal OL development or function may affect brain myelination.
