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Contamination of the skin may affect absorption and efficacy, especially if the contaminant interacts with the drug [14].
Doxycycline is commonly used for antibiotic prophylaxis before dilation and evacuation (D&E) but frequently causes nausea and emesis which may affect absorption and effectiveness.
Gut microflora, ethnic origin, and dietary context may affect absorption, metabolism, and bioavailability of isoflavones (32).
For example, decreased gut motility may affect absorption and increased plasma volume, water content and fat content may affect the distribution of the drug [ 10– 10].
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Circadian variations in gastrointestinal functions, hepatic and intestinal enzyme activity and organ blood flow may all affect absorption, distribution, metabolism, and elimination of drugs, including tamoxifen.
Moreover, Deane et al. [ 32] recently reported that absorption at the luminal surface is impaired and small luminal motility may affect lipid absorption in critically ill patients.
Many factors influence alcohol absorption, yet few studies have addressed the issue of whether or not experimental manipulations themselves may affect alcohol absorption.
Some antacids may affect the absorption of other drugs by binding with them in the gastrointestinal tract.
Quantitative and qualitative differences in intralumenal bile acids may affect cholesterol absorption and metabolism.
Ethanol may affect the absorption and metabolism of folate, leading to a reduction of the potential beneficial effect of folate intake on depression reported in men [51], [52], [53].
Iron status is one factor that may affect manganese absorption.
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