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These results suggest that GDP-bound ATLs may adopt multiple conformations and the in vitro fusion activity of ATL cannot be achieved by a simple collection of functional domains.
This observation does not necessarily mean that ATL will switch from "post-fusion" to "pre-fusion" directly in the presence of GDP, but rather raises the possibility that GDP-bound ATL is simply flexible and may adopt multiple conformations before releasing GDP and recycling GTPase.
Therefore, it is likely that Get3 may adopt multiple conformations to interact with the TMD of TA proteins.
It has been suggested that the EphA1 dimer may adopt multiple conformations.
Mounting evidence suggests that the protein and ligand may adopt multiple binding modes due to the inherent flexibility of the protein and ligand.
This has been shown to be important to accurately estimate the affinity of small fragments, which by having a limited number of interactions with the protein, and less shape complementarity requirements as compared to drug-like molecules, may adopt multiple binding modes with similar thermodynamic stability.
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Patients' concerns regarding the burdens of life with medications may be key factors to determining patients' willingness or unwillingness to adopt multiple medications; an unwillingness to adopt medications may be grounded in legitimate concerns.
Concerns about reliability, however, have limited the use of docking in fragment discovery: fragments can adopt multiple orientations in the binding site, and scoring functions optimized for larger, drug-like molecules may be inappropriate for fragments.
In the past, to get this level of protection, companies had to adopt multiple products.
This means that the same sequence can adopt multiple conformations.
Interestingly, the PBD is found to adopt multiple conformations.
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