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Thus, Nup53 might not only have an important function in binding to the pore membrane in turn promoting the recruitment of other nucleoporins, especially members of the Nup93 complex, but may additionally function to deform the NE membrane into a pore.

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Secondly, pharmaceutical interventions such as metformin and thiazolidinedione [ 27], as well as additional known strategies to effectively lower IR- healthy dietary pattern [ 28], regular exercise [ 29], or weight reduction [ 30]- may additionally improve walking function and prevent functional decline, especially for high-risk subjects.

These potentially contradictory effects of IGFBP-5 in bone are further complicated by observations indicating that IGFBP-5 additionally may function in an IGF-independent way, and may have been accentuated by differences in both experimental design and methodology among published studies.

Extracellular signal activated kinases such as AKT, which are often activated/overexpressed in therapy resistant breast cancers, may additionally alter these functions of E2 to modify the course of the disease.

Additionally, function may only become apparent after detailed analysis, as demonstrated for C. elegans mir-1, which regulates synaptic signalling at neuromuscular junctions and influences sensitivity to levamisole [ 27].

The presence of Na-FAR-1 in the parasite's intestinal cells may indicate involvement in transportation and storage of lipids derived from host blood and its location in copulatory bursa of male worms suggests its function may additionally be related to reproduction.

Ku's interaction with TRF2 may not only inhibit its c-NHEJ function but may additionally promote the execution of its protective telomeric functions, which are to inhibit alt-NHEJ and HDR (Bombarde et al., 2010; Sfeir and de Lange, 2012) and prevent dramatic telomere deletions in human cells, an essential function (Wang et al., 2009).

Knowledge-based scoring functions may additionally or exclusively use other types of interaction quantities that are parameterized using training set(s) to fit the data (for review see: [6, 7]).

A diurnal pattern of its expression has been also observed in the amygdala, where it may additionally exert non-circadian functions.

However, given the known interactions of Cas proteins with FAK and SRC at focal adhesions, another possibility is that Cas may additionally or alternatively impact Shg function through indirect signaling emanating from these structures.

Other binding partners may additionally contribute to the anti-apoptotic function of survivin-ΔEx3.

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