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The exceptional suppression of ERK-mediated activation suggested that these potent γ-secretase modulators may adapt an alternative pathway to prominently induce the differential inhibition of C99 cleavage by γ-secretase.
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A council panel is studying ways to select a provisional government by spring, and may adapt a version of the caucus plan.
In this state, tumor cells may adapt a Warburg phenotype and CSCs cellular states should have a powerful growth and survival advantage.
Further, the PML/RARa chimera may adapt a different conformation that renders it more prone to aggregation than PML or RARa expressed from non-rearranged genes.
Following a protocol amendment detailing how the study and analyses may adapt, a reestimation of the sample size commenced with use of a new model with a revised structure, new OKZ PK parameters from the first-in-human PK model, and adapted PK/PD parameter estimates based on preclinical in vivo and in vitro data for resimulation (two parameterizations receiving equal weight).
Alternatively, precursor stem cells may adapt to an androgen-deprived environment and differentiate in the absence of androgens.
In this manner, sylvatic species may adapt to an anthropomotic transmission, and reinvasion of insects from sylvatic transmission cycles becomes a major challenge for Chagas disease control [ 19, 20].
It is likely that bacteria that are internalized, and under selective pressure, may adapt to an otherwise hostile microenvironment by switching on novel gene expression that enables them to utilize cytokines as their growth factors.
Still, the Credit Suisse deals show that Wall Street may adapt to a more regulated era and that transactions will still go smoothly.
These results suggest that SOMs may adapt at a faster time scale than PVs with repeated presentation of tones.
However, the development of erosion is gradual, and many elderly people may hesitate to seek medical care; instead, they may adapt to a sedentary lifestyle.
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CEO of Professional Science Editing for Scientists @ prosciediting.com