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Since Gli2 is well-recognized as the main transcriptional effector of Shh signaling in granule neuron precursor cells that form the cerebellum [16], this suggests that loss of Pten may actually attenuate signaling through Shh signaling pathways.
Finally, HCA may actually attenuate the development of hypoxia-induced pulmonary hypertension by reducing oxidant stress [ 7].
Paradoxically, there are a growing number of studies correlating lower FAK levels with poorer patient survival [ 25, 26], suggesting that FAK may actually attenuate some of the lethal parameters of cancer progression.
The immunohistochemical characterization of AD hallmarks observed in transgenic mice in this study shows that the EB101 vaccine may not only halt AD-related pathology but also may actually attenuate it, leading to a robust immunological response and an anti-inflammatory effect as well.
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And, as was discussed, this may have actually attenuated between-group differences (i.e., conservative bias).
One thought as to why vaccination against cancer antigens may have had limited success has been that vaccination may augment induction of Tregs, which actually attenuate effective immunity to the tumor [ 35].
The actual mechanism through which IPC and IPost actually attenuate oxidative stress at the time of reperfusion is not clear.
Beyond 300 ms the second response is actually attenuated.
Finally, we were unable to confirm in our in vivo studies whether ALDH2 activity was actually attenuated by GTN.
Some of the patients who in previous studies were viewed as having attenuated psychotic symptoms may actually have had a very early episode of schizophrenia.
Indeed, rather than attenuating conflict, contact between different groups may actually increase tension [ 27, 29].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com