However, all living tumor and nontumor cells may also actively release DNA as reported by Stroun et al. in 13.
Besides apoptotic and necrotic cell death, living cancer cells may also actively release RNA into the blood circulation (Stroun et al, 2001).
Because all cells appeared morphologically normal and healthy, the above result suggests that PEPD may be actively released by the cells.
Both models support the possibility that miRNAs may be actively released into circulation and could act as signaling molecules able to regulate their target mRNA expression in recipient cells.
Because diseased cells, including tumor cells, actively release exosomes into the blood stream, the circulating exosomes may provide a stable source of RNAs for disease diagnosis, prognosis and treatment management [ 2, 6, 39, 48].
As renal cells along the nephron actively release EVs into the urine, variations in uEV number, origin or content may mirror the physiopathological state of the kidney, representing an interesting field of investigation in search of possible disease targets, markers or new therapeutic agents.
These findings clearly indicate that neuronal cells actively release membrane-derived MVs in addition to exosomes [61].
Furthermore, mast cells are present and actively release their granular material throughout development.
To visualize whether these extra synapses actively release neurotransmitters, we performed an FM4 64 labeling experiment.
It was previously unknown whether inflammatory stimuli can induce hepatocytes to actively release HMGB1.
