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While men with the minor allele of this polymorphism appeared to have no additional benefit of NSAID use, it is plausible that NSAID use may actively inhibit COX2 enzymatic activity only among those with the more prevalent major allele, while those with the variant allele may reach a threshold of COX2 inhibition such that NSAID use provides no added protection.
It was previously reported that F. tularensis may actively inhibit the production of TNFα by macrophages and even compete with LPS [33].
Second, the pallidum may actively inhibit the motor cortex during voluntary movements.
Although it cannot be excluded that metformin treatment may actively inhibit production of new senescent cells (thus decreasing their "normal" frequency of accumulation in aging tissues) the fact that senescent cells are turned over slowly strongly suggests that metformin may enhance immune system responsiveness to senescent cells (thus increasing their "normal" clearance rate in aging tissues).
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These results suggest that ATP not only competes for the activator AMP, but may also actively inhibit AMPK by inducing a conformation distinct from that induced by AMP.
Secondly, cells of the mesodermal and endodermal germ layers that also develop in these other assay systems may release signals that actively inhibit neuronal differentiation.
38 Defects in synaptic basal lamina may thus be involved in ALS, particularly in laminin β2 that has been shown to actively inhibit TSC entry into the synaptic cleft.
What is there to actively inhibit if there are no stimuli eliciting feeding behavior?
Primary AOXs actively inhibit oxidation reaction.
Jiadifenoic acids C can actively inhibit replication of CVBs as well as the pleconaril-resistant CVB3.
Whether the microenvironment can actively inhibit tumour progression has not been well studied.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com