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We demonstrated that MVs from endothelial progenitor cells may activate in normal endothelial cells an angiogenic program by transfer of functional mRNAs [4].
The release of calcium stores sequestered within intracellular organelles raises the cytosolic concentration of free calcium, a process that may activate, in turn, a number of membrane-disruptive processes.
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In addition, IR causes a compensatory increase in insulin secretion that in turn may activate mTOR in the retina.
Numerous studies have shown that both free fatty acids and high glucose levels in diabetes may activate PKC in various vascular cells via de novo synthesis of diacylglycerol (DAG) [ 41].
In this sense, the extracellular ligand that may activate Smad3 in the DG to inhibit adult neurogenesis remains unknown.
In summary, this study demonstrates that hay dust may activate Hif1 in horse myeloid cells.
This leads, in turn, to an augmented release of adenosine, which may activate A1R in afferent arterioles [14].
The soluble ligand can bind and activate EGFR in an autocrine or paracrine manner, while the transmembrane (pro) form may activate EGFR in adjacent cells (juxtacrine).
Here, we remove all doubt that cells devoid of Rab11 may activate Notch in their neighbors.
This result suggests that cytokines such as TNF-α, which can be released upon epithelium-lymphocyte intereaction [20], may activate AMPK in epithelial cells to accelerate TJ assembly.
Since phosphorylation of IRF7 is thought to be catalyzed by TBK1/IKKi [27], TRAF6 may activate TBK1/IKKi in response to cytosolic RNA and DNA.
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