Sentence examples similar to may activate dna from inspiring English sources

Recent studies have shown that inactivation of DNA-PKcs by siRNA or kinase inhibitor, Nu7026, results in dysfunction of mitotic checkpoint and attenuation of Chk2 phosphorylation at Thr68 in response to IR. Together with our results, both DFO and IR may activate DNA-PKcs to induce phosphorylation of Chk2.

UV irradiation induces DNA damage and histone modification, which may activate various DNA repair genes, including p53 [20].

The biological and molecular aspects monitored strongly indicate that malten exposure may activate a DNA damage response.

Moreover, it may be relevant to evaluate whether metformin-altered cancer risk and improved health of laboratory animals may relate to its ability to activate DNA damage-like signaling to induce specific senescence-like growth inhibition of premalignant or malignant cells without altering normal breast structures or other non-neoplasic tissues.

There are numerous factors that might have an impact on PARP-1 activity; DNA-PK may activate PARP-1 by phosphorylation (Ruscetti et al, 1998) or suppress PARP activity through sequestration of DNA ends that serve as an important stimulator for both enzymes (Ariumi et al, 1999).

The same DNA containing immune complexes may activate TLR 9 in DNA-reactive B cells to promote their survival through tolerance checkpoints and to help them class switch to production of the proinflammatory IgG isotype.

It is well established that bacterial DNA sequences, by virtue of different methylation pattern from mammalian DNA, may activate the immune system (Sato et al, 1996; Klinman et al, 1997).

DNA may activate Wss1 in two ways.

The author discusses practical considerations when attempting to influence the activity of this process, as although DNA methyltransferase blockade may activate tumour suppressor gene expression, the paradoxical activation of metastasis-associated gene expression could also be unleashed.

These data demonstrate that pCHK1S345 is specific for ATR and that camptothecin-induced DNA damage may activate ATM to phosphorylate pCHK1 on Ser317 but hydroxyurea-mediated damage is signalled to CHK1 only via ATR.

Cells that achieve rapid recognition and repair of DSBs may not initiate a p53 pulse in response to damage, while cells that are slower in their response to DNA DSBs may activate p53 to induce cell-cycle arrest and allow additional time for repair.