Restart it to activate changes.
Cell-cell interactions are relevant in modulating the response to external stimuli, and modifications of membrane and/or matrix components may activate signaling events that change cell fate [34].
The activity of c-Abl is under tight control, and binding of the c-Abl SH2 domain to its binding partners causes a conformational change that may activate the kinase [ 19].
This in turn may activate protein kinase C (PKC) causing changes in pain perception (Pacher et al. 2007).
Therefore, while an agent like metformin may activate AMPK without producing a detectable change in adenine nucleotides, this does not prove that the effect is AMP independent.
Alternatively, changes in beating calcium may activate hypertrophy through mechanical stretch pathways.
The focal nature of nuclear positivity may reflect the induction of this pathway in a subset of cells that has acquired new genetic or epigenetic changes that activate NF-κB and thus may activate downstream anti-apoptotic pathways.
Hormone signalling may also trigger transcriptional changes at transcription factor genes, which in turn may activate different defence response genes (see next section).
Todani et al. [21] reported that the reflux of bile may activate pancreatic enzymes, which can cause chronic inflammation and metaplastic epithelial change in the pancreatic duct, and pancreatic cancer may eventually develop.
First, unmodulated tones may activate suppression along their temporal extent as, in contrast to FM sweeps, their frequency composition does not change over time.
