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High-dose SB may activate both components of the coronary vessel wall, as well as other non-NO-mediated signaling mechanisms, whereas low-dose SB seems to produce a coronary-specific and endothelium-dependent NO-mediated activation [12].
Therefore, our observations that under glucose restriction the ATM is phosphorylated at Ser-1981 in HDFs are consistent with the possibility that energetic-stress induced kinases, such as ARK5, may activate both ATM and p53.
First, because electrical stimulation in the optic nerve layer may activate both eNpHR-expressing retinal axons and V1-derived eNpHR non-expressing axons, the laser illumination-resistant component of the EPSCs may have been caused by V1-derived synaptic input.
Delivery of antigen into the skin by MN, which are inserted into the epidermis and the upper layer of the dermis, may activate both LC and dermal dendritic cells (DCs) which in turn convey the antigen to the draining lymph nodes [1].
As shown in Figures 1 and 2, it seems that trauma may activate both dimensions concomitantly.
Although GEFT may activate both Rac1 and Cdc42, its effect on neurite growth is possibly via Rac1/PAK pathway [ 98].
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This creates opportunity of development of hybride analgesics that may simultaneously activate both opioid and NT antinociceptive pathways.
Although we have not proved it directly, we speculate that oxidants contained in cigarette smoke may activate p53 through both caveolin-1/ATM and caveolin-1/Mdm2-dependent mechanisms.
It is likely that higher doses may activate non- specifically both BGL lowering and rising mechanisms.
These results suggest that oxidative stress may activate Muller glia to both protect and replenish retinal neurons.
Stimulation of GIRK channels and β-adrenergic signaling may activate similar signaling pathways in both SCLC and breast cancer, but lead to different results.
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