Sentence examples for may activate apoptosis from inspiring English sources

Contrary to the ABC hypothesis, Michaels et al. hypothesize since hCG plays a role in cellular differentiation and may activate apoptosis, as levels of hCG increase early on in human pregnancy, "an incomplete pregnancy of short duration might impart the benefits of a full-term pregnancy and thus reduce the risk of breast cancer".

As suggested by [ 4, 5], nanoparticles may activate apoptosis.

Alternatively, overexpression of BRCA1 may activate apoptosis or cell death [ 14].

TGF- β1 has recently been shown to activate caspase-3 to induce apoptosis in the NRP-154 prostate epithelial cell line (Chipuk et al, 2001), evidence supporting our hypothesis that doxazosin may activate apoptosis of prostate cancer cells through TGF- β1 signalling.

Thus, TNFα may simultaneously activate apoptosis and cell survival pathways, two conflicting biological processes, in human colon carcinoma cells.

Many intracellular stress circumstances, including DNA damage, oxidative stress, cytosolic Ca2+ overload, accumulation of unfolded proteins in the endoplasmic reticulum and many others may also activate apoptosis.

An accumulation of damage products, e.g. ROS, may also activate apoptosis-associated proteases (e.g. caspases) for PARP-1 cleavage [ 26].

One fundamental reason for treatment failure is that it is designed to activate apoptosis genes (eg, TP53) that may be unavailable because of mutation or deletion.

Moreover, caspase activation links CHOP to both pro-inflammatory mediators and apoptosis, and ER stress may activate the mitochondrial apoptosis pathway.

Moreover, since radiation and many chemotherapeutic agents can activate apoptosis or senescence, the integrity of these anti-proliferative programs may influence the outcome of cancer therapy in patients.

ER stress may activate the mitochondrial apoptosis pathway.