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dpp and daw, as secreted signals, may act systemically to regulate other target genes in other tissues throughout the animal.
These peptides are released into the central circulation and may act systemically, as opposed to many of the known mediators of sepsis, which are released locally and often act in an autocrine or paracrine fashion.
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Oral bacteria may activate alcohol and smoking-related carcinogens locally or act systemically, through chronic inflammation (Ahn et al., 2012).
With the understanding that PM can act systemically, rather than impacting only the lungs, emerging evidence suggests there may be specific susceptible populations other than those already identified.
For molecules intended to act systemically using the lung as a portal of entry into the circulatory system, absorption and resulting systemic levels are obviously extremely important.
Thinking in the big picture, these folks think and act systemically.
Rather, doctors typically act systemically, using chemotherapy and radiation in attempt to obliterate the cancer.
Prosecutors have failed to act systemically to ensure that every Burge victim gets the hearing that is his due.
Since ADAM17 sheds factors that can act systemically [17], it is possible that extrathymically derived factors influence intrathymic development.
Importantly, NGF has the potential to act systemically on distant organs, including the bone marrow which serves as the primary site of postnatal hematopoiesis[14], [15].
Several lines of evidence suggest that PNPs can act systemically.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com