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α-MSH may act specifically to regulate PGD2 synthesis at the level of L-PGDS (Fig. 2f).
PHLDA2 may act specifically to limit the transport of factors required for skeletal growth, for example by limiting calcium transport.
There is, therefore, a need to develop new methods of inhibiting aromatase activity that may act specifically within the breast but spare other oestrogen-sensitive tissues.
The mitochondrial group was included because SIRT3 is a mitochondrial-localized protein, and factors which regulate its expression may act specifically on nuclear-encoded mitochondrial genes during processes induced by nutrient stress such as mitochondrial biogenesis (e.g., Scarpulla, 2002).
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Concerns regarding the development of siRNAs to VEGF have also arisen as they may act non-specifically [7].
However, they do not act specifically on AP [19].
Since Hh signaling plays a crucial role during embryonic and postnatal vasculogenesis, we speculated that Hh ligand may act on tumor vasculature specifically focusing on bone marrow (BM -derived cells.
Alternatively, or in addition to, maturation of inhibition within the MeA at puberty may act to silence, or specifically shunt less robust MeA responses.
Specifically, MMP-2 may act directly by degrading ECM components like type III collagen or indirectly by activating pro-MMP-2 or by inducing tumor angiogenesis through vascular endothelial growth factors (Tetu et al. 2006).
This suggests that some biological mechanisms for AD susceptibility may act through both SNPs and CNVs (specifically, deletions).
Their results strongly support the concept that extravascular plasma proteins may act as damage-associated molecular patterns, and specifically as Toll-like receptor 4 agonists.
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CEO of Professional Science Editing for Scientists @ prosciediting.com