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Interestingly, the two types of change are not significantly associated (that is, genes showing one type of change are not more likely to show the other), suggesting that the two types of changes may act largely independently.
Simultaneously, pericentral FOXO-mediated autophagy may act largely unaffected ensuring protection against increased risk of cell deterioration due to decreasing pericentral oxygen concentrations.
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This indicates that these two hormonal pathways act largely independently in the control of floral transition.
IFNγ appears to act largely through a transcriptional mechanism on the FXN gene.
It has been suggested that gap factors act largely as transcriptional repressors (Schroeder et al., 2004).
However, very little is known about the molecular function of Trk receptors in melanocyte biology, and the exact mechanisms by which the NGF-TrkA signaling may act in melanocytic disorders remain largely unknown.
This causes significant seasonal variations in vertical carbon fluxes, which seems to be not only very important for the dynamics of viral [ 27] and bacterial communities [ 56] in such systems, but also for protistan communities, even though the exact mechanisms for how vertical carbon flux variations may act on protistan communities are largely unknown.
First, the available studies have largely focused on single chemicals and have ignored the possibility that large numbers of agents may act in concert.
It is thought that certain dietary AGEs are largely undigested by human gut enzymes and eventually enter the colon, where they may act as a growth substrate for detrimental bacteria such as some Clostridium and Bacteroides species [ 34].
Yet this results largely in broad classifications of tumors, which to the best of our current understanding may act quite differently on a biological level.
The dietary constituents that may act, in the broadest sense, as co-factors to enable bacterial enteropathogens to replicate in gastrointestinal environments are still largely unknown.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com