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A worrying implication is that bacteria may acquire resistance even when antibiotics are used prudently or not at all, says Carlson--although it's not clear how often this happens.
By the same mechanism cancer cells may acquire resistance to EGF pathway inhibitors.
Antiviral drugs of the neuraminidase inhibitor group have been used effectively against influenza viruses but might not be in sufficient supply and the virus may acquire resistance to the available antiviral drugs [8].
At present, neuraminidase (NA) inhibitors such as oseltamivir and zanamivir have been efficacious against the current H1N1 strain of swine origin; however, the virus may acquire resistance to the available antiviral drugs.
Tumors may acquire resistance during anti-angiogenic treatment or show intrinsic resistance.
E. coli may acquire resistance for both antibiotics in the same way.
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Bacteria may also acquire resistance genes through the spread of transposons or integrons, groups of linked genetic elements.
Tumours may also acquire resistance by additional mutations in the BRCA1 & BRCA2 gene [ 8– 10] and so there is a place for further investigation of DNA repair inhibition in HR defective tumours.
Beijing strains particularly may tend to acquire resistance more easily than others under conditions of suboptimal treatment (9 ).
Those findings highlight that even though A. baumannii is usually recognized as a final acceptor for resistance genes, it may acquire several resistance determinants and then transfer them to Enterobacteriaceae and Pseudomonas spp. Since the first description of NDM-1, eight variants of this enzyme have been published (NDM-1 to -8) and ten have been assigned (http://www.lahey.org).org
In theory, ingestion of plasmids or DNA fragments containing the resistance determinants might also pose a risk because the human microbiota may acquire the resistance genes by transformation.
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