Sentence examples for may acquire mutations from inspiring English sources

For example, a strain may acquire mutations that induce antibiotic resistance or facilitate evasion of the host immune response [21].

After duplication, both the regulatory and coding sequences of the paralogous genes may acquire mutations or be subjected to epigenetic effects that affect both the functions and expression patterns of the genes.

Normal stem cells with inherent self-renewal capacity may acquire mutations and become transformed.

Although antibiotic tolerance in persisters is thought to be phenotypic, it is possible that under some conditions, antibiotic tolerant persisters may acquire mutations and develop genetic resistance.

Finally, bacteria may acquire several genes for a metabolic pathway which ultimately produces altered bacterial cell walls that no longer contain the binding site of the antimicrobial agent, or bacteria may acquire mutations that limit access of antimicrobial agents to the intracellular target site via down-regulation of porin genes [ 21].

Cells that have acquired a proliferative advantage through proviral mutation of cellular genes, may acquire additional mutations by viral reinfection and eventually develop into tumors (reviewed in Uren et al., 2005).

It should be noted that resistant strains that have low fitness may acquire compensatory mutations and hence increase their fitness over the long-term.

This might suggest that these tumours may acquire fewer mutations than ones in non-stem cells and therefore they may be more sensitive to treatment.

Other genes in these organisms may acquire genetic mutations that enable the genes to take on the role of the missing protein.

In addition, the tumor cells may acquire subsequent mutations which make them resistant to inhibitors that target the original activated oncogene.

This may be interesting if low-passage xenografts are desired, as it has been shown that similar to cell lines xenografts may acquire additional mutations and changes in the karyotype [ 17, 12]; and it is very convenient in relieving laboratories from the necessity of continuous passaging.