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In addition, these results may not adequately reflect long-term effects of treatment as different drugs may achieve maximal effect and lead to side effects at different rates.
Moreover, the conditions under which the regenerative treatment may achieve maximal MSC and resident NP cell performance - even in advanced stages of IVD degeneration - could be improved by creating an optimal biomechanical environment.
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While selection bias remains a possibility, our results support the notion that having strict eligibility criteria may assist in determining the cohort of patients who may achieve the maximal benefits of this procedure, and conversely, those that may not benefit from it.
These data suggest that prolonged use of VEGF-targeted therapy may be necessary to achieve maximal therapeutic benefit.
The increasing clinical exploration of agents that induce ER stress and apoptosis in myeloma cells, such as proteasome or NEDDylation inhibitors, HSP90 inhibitors and histone deacteylase inhibitors, underscores the importance of furthering our understanding of how these pathways may be manipulated to achieve maximal cytotoxic effects in malignant plasma cells.
Complete inactivation of AGAT may not be necessary to achieve maximal clinical activity.
If these programs are to be successful, it is not only crucial to carry out comprehensive follow-up, but to recognize that men and women may require different approaches to achieve maximal benefit from treatment for CAD.
Thus, a necrotic mechanism – in particular, direct SC-necrotic myocyte contact –may be necessary in order to achieve maximal myogenesis with collagen matrix treatment.
[ 13] Communities wishing to achieve maximal availability of sterile syringes may opt to offer all avenues of access to sterile syringes.
Additionally, mechanistic data suggest that crosstalk exists between the MAPK and PI3K pathways, and thus to achieve maximal effects inhibition of both pathways may be necessary (Ma et al, 2005, 2007).
In addition to chemostat cultivation, the photobioreactor may also operate as a turbidostat, continuously adjusting the media dilution to achieve maximal growth at a fixed culture density.
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