Agents designed to activate the cell death machinery directly, for example by activating the death receptors expressed by melanoma cells, could break drug resistance, and they may achieve long-lasting therapeutic success.
However, some cases [15] may achieve long-term survival after resection, and aggressive resection should be performed with curative intent where possible.
As in this case, repeat metastasectomy may achieve long-term survival after primary resection of the PDAC; the present case is considered to have relatively "good biology" and be a potentially good candidate for metastasectomy of recurrence.
It is difficult to make any definite comments; however, the current results suggest that patients with small and solitary metastatic liver tumor of MCC may achieve long-term survival following hepatic resection, and hepatic resection may be justified for these patients.
The percentage of these was higher than I expected, which made me hopeful that humanity may achieve long-term survival without regressing to a resemblance of the Flintstone cartoons.
Under these preconditions, RNAi therapy may achieve long-term cardiac benefit without apparent toxicity.
Although some patients may achieve long-lasting relief of symptoms after injection(s), many often fail to respond to subsequent injections and are operated on (Armstrong et al. 2004, Verdugo et al. 2008).
Salvage chemotherapy should be given with curative intent and published series suggest 20 57% of patients may achieve long-term disease-free status with this and subsequent salvage therapy (Motzer et al, 1991, 2000a, 2000b; Pizzocaro et al, 1992; Miller et al, 1997; Bhatia et al, 2000).
Patients with a resectable primary tumor and a single metastatic site in the brain or adrenal gland may achieve long-term survival with an aggressive multimodality approach even though this practice could not be supported by the present study[ 10 12 ].
Metastasectomy may achieved long-term survival after primary resection of the PDAC Studies of more such cases are needed to address this issue.
