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Unlike existing nongated synchronization approaches where slices are synchronized to neighboring slices and errors may accumulate with each round of synchronization, in the STAR method, there is no accumulation of the error since all slices are synchronized to the same signal.
It has been reported that quercetin metabolites are retained within plasma for periods of time ranging from 30 min - 11 h [10], [11], and these slow rates of excretion together with bioavailability profiles of metabolites of this flavonol (100 mg of quercetin from onions or quercetin-4'-glucoside - 7-7.6 µM quercetin in plasma (11)) suggest they may accumulate with repeated dietary intake.
Second, metabolites may accumulate with AKI.
Also, DXA emits a small amount of radiation, which may accumulate with repeated measures and may not be acceptable to some research participants.
Moreover, canopy soil and other epiphytes may accumulate with time and may change the substrate quality on long-lived tree individuals.
Therefore, in tissues where estrogen levels are continuously high, AID-driven aberrations may accumulate with time, which in turn might contribute to the development and/or progression of estrogen-dependent tumor types.
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Finally, Z chromosomes may accumulate genes with male-biased functions and consequent male-biased expression, which could be mistaken for, or could result in, a lack of dosage compensation.
MALA may develop without an underlying disease or may aggravate LAOO, or metformin may accumulate just coincidentally with LA [ 3, 12].
Since LMWHs are mainly excreted by the kidney, they may accumulate in patients with renal insufficiency increasing the risk of bleeding [ 17– 17].
Serotonin reuptake inhibitors are Cyt P450 substrates and may accumulate in individuals with slow metabolism or if Cyt P450 is inhibited.
This is consistent with a scenario in which deleterious changes are strongly purged from rate-limiting enzymes, because they alter pathway flux, but such changes may accumulate in enzymes with less control over flux (Mannakee and Gutenkunst, manuscript submitted).
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