Sentence examples for may accumulate mutations from inspiring English sources

Individual satellites may be either eliminated by excision or may accumulate mutations and lose its repetitive nature.

In general, genes that are not expressed may accumulate mutations, including mutations in residues critical to the normal function of the protein.

On the other hand, the inactive allele may accumulate mutations that remain unexposed as long as the sex of the transmitting parent does not switch [ 5].

Both copies may be retained in the polyploid and remain functional, one copy may accumulate mutations and either diverge in function or become silenced, or one copy may be physically lost [ 8, 33, 34].

Most other cow tRNA genes have accumulated at least one point mutation during the evolution of the vertebrates, since a tRNA gene may accumulate mutations while still retaining biological function.

Alternatively, one of the copies of a duplicated gene can be removed from selective pressure due to functional redundancy, and thus under neutral evolution may accumulate mutations that confer a novel function [ 54, 55].

To achieve optimal fitness, a mutation with a conditionally detrimental effect in a population can either be selected out, or else other mutations may accumulate (mutation accumulation) to compensate the antagonism (Orr 2000; Pavlicev and Wagner 2012; D'Souza and Wagner 2014).

Although the precise role of stem cells in tumourigenesis is still in debate, it is widely accepted that cancers can arise from normal stem cells which may accumulate mutation, genetic changes, and molecular pathway alterations that disrupt self-renewal control capacity (Table 1).

They may therefore accumulate mutations that result in transformation [ 6].

Although errors in mtDNA replication have been demonstrated to produce inherited mitochondrial defects and aging in mice (Ross et al. 2013), animal mtDNA may also accumulate mutations in part because aerobic respiration generates mutagenic ROS in close proximity to mtDNA.

In addition, no personal genome has been so extensively analyzed using DNA derived from peripheral blood as opposed to DNA from transformed cell lines that may either accumulate mutations during propagation or clonally expand mosaic variants during cell transformation and propagation.