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"Inflammation may accelerate aging in some people — but it is a manifestation of something that is occurring underneath".
Additionally, ROS may accelerate aging process and cause uneven pigmentation.
Recent studies suggest that chronic psychological stress may accelerate aging at the cellular level.
Finally, as suggested by other retinal studies (Tan et al. 2001), the increased number of rods in GLE mice may accelerate age-related retinal degeneration.
It can also be caused by the perturbation of mitochondrial homeostasis (Fig. 1), which may accelerate age-related phenotypes (Sahin & DePinho, 2010, 2012).
Short-term improvement in neurocognitive function associated with a decline in blood lead concentration does not obviate concern that long-term cumulative lead exposure may nonetheless have a deleterious effect on cognitive reserve, and may accelerate age-related decline in cognitive function (Schwartz et al. 2005; Weisskopf et al. 2004).
These results suggest that progeny production may accelerate aging.
Furthermore, both insulin and chemotherapy may accelerate aging.
Preclinical and childhood cancer survivor studies show that therapies including chemotherapy may accelerate aging [58], [59,60].
Several HGPS-progeroid mouse models have been established to investigate how Lmna mutations, including defective processing of normal Lamin A, may accelerate aging [ 39- 45].
As such, it is widely acknowledged that decreased GH/IGF1signaling in mice can extend lifespan, while increased GH levels may accelerate aging [ 4- 5].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com