Maximum work capacity was tested on a cycle ergometer and converted to VO2max.
On the first day, the practice nurse or the laboratory technician tested maximum work capacity (Wattmax) and muscle strength and measured weight, height, waist circumference, blood pressure and HbA1c.
Then, after a resting period of 2 hours, they performed a constant work-rate exercise test at 90% of the maximum work rate calculated from the incremental test.
Methods: In 203 subjects from the NETT Genetics Ancillary Study, four outcome measures were used to define response to LVRS at six months: modified BODE index, post-bronchodilator FEV1, maximum work achieved on a cardiopulmonary exercise test, and University of California, San Diego shortness of breath questionnaire.
Estimating maximum work rate during incremental cycle ergometry testing from six-minute walk distance in patients with chronic obstructive pulmonary disease.
Constant work rate cycle ergometry testing at 75% maximum work rate was conducted pre-dose at Day 1 (baseline) of each treatment period (Visits 1 and 3), and at 3 h post-dose at Week 3 of each period (Visits 2 and 4).
Patients who cycled <2 min or >20 min during exercise testing at 75% of maximum work rate during the run-in visit or Visit 1 (pre-randomization) were not permitted to continue in the study.
Work rates were adjusted to correspond to 90%% of each individual's maximum work rate determined by the maximal graded exercise test under normoxic conditions and ranged from 216 to 288 W (mean work rate 270 W).
For Wmax6, the test result is an estimate of maximum work sustainable for 6 min 34 and is in young men correlated with maximum oxygen uptake (r=0.9).
A symptom-limited incremental cycle exercise test was performed at screening to determine the maximum work rate that patients were able to maintain for ≥30 s.
