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Severity score (simplified acute physiology score II (SAPS II) [10]) and organ dysfunction (sequential organ failure assessment score (SOFA) [11]): we defined severe organ dysfunctions as a SOFA score of 3 or 4; among daily SOFA scores, only the maximum was included in the analysis;   5.

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When a small amount of noise, such as the variability due to sampling imprecision hampering the perfect localization of a local maximum or minimum, is included in a birhythmic system, the bisecting lines appear as two narrow bundles of lines rather than two single lines, e.g. the birhythmic Verhulst system in Figure 8, right.

A total of 19 studies with a mean follow-up time of 4.6 years (maximum 15.1 years) was included (Table 3).

A total of 6 studies with a mean follow-up time of 12.5 years (maximum 16.5 years) was included, of which only 4 qualified for the numerical analysis (Table 5).

If publications reported on the same sample or on overlapping samples, the publication providing the maximum of information was included in the meta-analysis.

Models were as outlined above, with the exception that the binary variable for exceeding alcohol intake guideline ('within guidelines: ≤4 standard alcoholic drinks' versus '≥5 standard alcoholic drinks') in typical and maximum AmED session was included in Step 4. Across all analyses, significance levels were maintained at p < .05.05

An exponential placebo model with factor for maximum placebo response (MPL) was included in the model to empirically account for the effect of placebo on HbA1c levels observed in this short-term (12 weeks) trial.

In the analyses of maximum on-treatment ALT and maximum on-treatment TBL, baseline was included in the model as a covariate.

For computational reasons, a maximum number of eight individuals was included per haplotype.

Where the practice was unable to generate 1,150 patients (due to smaller list sizes) the maximum number of patients available was included.

Lastly, the exclusion of patients for whom therapy was withheld due to non-survivable injuries could be considered as a limitation potentially introducing bias, as no patient with the maximum ISS score of 75 was included in the study.

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