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The developed algorithms were verified by comparing their results with the results obtained by a commercial instrument and the maximum variation between the two results did not exceed than ±2.27%.
Prior to the event, the scales were examined for consistency, and though the maximum variation between scales was less than 0.5%% across the weight range of our subjects, correction equations were developed to standardize all weight measurements to a single scale.
In contrast to PCA, which is an unsupervised multivariate statistical classification method that works to explain maximum variation between samples, PLS-DA is a supervised method that explains maximum separation between pre-defined classes (e.g. genotype or health state) in the data.
The linear range of the assay was 0.2 20 ng ml−1 and maximum variation between assays was 5% of the mean.
In exchange for funding, project leaders and clinicians agreed to develop and implement a disease management program that meets the needs of their patient population and to facilitate qualitative, quantitative, and economic research conducted at the site [ 14]; five were selected for further in-depth qualitative research, based on maximum variation between diseases and practices.
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The residues that display the maximum variations between the directions of fluctuations can also be visualized on the structures in Fig. 3, as color coded according to the change in the correlation values of p1-p6D30N/N88D (Fig. 3B, E) and LP1′Fp1-p6D30N/N88D (Fig. 3C, F) compared to p1-p6WT.
The structures in Fig. 4 display the residues that exhibit the maximum variations between the directions of fluctuations, as color coded according to the change in the correlation values of NC-p1V82A (Fig. 4B, E) and AP2VNC-p1V82A (Fig. 4C, F) compared to NC-p1WT.
The maximum variation observed between the chromatograms is illustrated by the red curve in Figure 1B.
We identified 830 genes with a maximum variation in expression between the five stages of <25% (see Additional file 2).
A maximum variation of 1 cm between the two measurements was allowed.
While lowering the sample size reduced the differences between maximum variation and the random strategies, increasing sample size to n = 18 did not change the ranking of the strategies and led to only slightly better predictions.
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