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In Sri Lanka, the maximum vaccination coverage achieved through parenteral vaccination and stray dog removal campaigns was 60%.
Three scenarios were estimated for the full range of budget constraints: (1) maximum screening coverage of 20% and maximum vaccination coverage of 95%; (2) maximum screening coverage of 40% and maximum vaccination coverage of 95%; and (3) maximum screening coverage of 20% and maximum vaccination coverage of 50%.
Detailed knowledge of the kinetics of maAb in fox cubs against rabies was missing, but is essential to optimise the timing of oral rabies vaccination campaigns in spring in order to achieve maximum vaccination coverage of the fox population [ 14].
"To be sure that we have the maximum vaccination coverage possible, the Ministry of Health, UNICEF and partners, we will undertake a mass immunisation campaign over a short period of time to try to reach 100% of the children in Mahama camp with fresh vaccinations.
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The scenarios varied by available budget, maximum screening and vaccination coverage, and overall reachable population.
Those scenarios varied by available budget and by constraints on the maximum screening and vaccination coverage to be reached and the overall reachable population.
With a $2 per woman budget constraint, the maximum vaccination and screening coverage is reached under the optimal mix of strategies for all sensitivity analyses performed, and hence the maximum CC reduction is reached with both the 3-dose and the 2-dose vaccination schedule scenarios and under all sensitivity analyses.
We have developed a model that would identify the optimal mix of CC prevention strategies (screening and or vaccination) to minimize the number of CC cases for different scenarios defined by constraints on budget, maximum screening and vaccination coverage, and overall reachable population.
In Figure 6a, we assume that all children receive TIV; children up to the maximum recommended age increase their vaccination coverage; older children are constantly vaccinated with the same coverage as in scenario 1.
Over a wide range of parameter values the maximum odds ratio occurs for effective vaccination coverage in the range 15-25%.
These results are used as input data to the assessment model allowing the estimation of the CC cases under the different vaccination coverage and the maximum impact of boys vaccination.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com