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Renal insufficiency worsened over time, evidenced by maximum urea levels of 57.3 mmol/L and maximum creatinine levels of 744 μmol/L.
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The following variables were measured before and at regular time intervals during the study for a maximum of 72 hours: urine output, heart rate (HR), mean arterial blood pressure, and serum albumin, creatinine, and urea levels.
Spectra are from the voxel with the maximum urea signal and zoomed on the urea peak to highlight the small differences of the spectra.
No patient had blood urea levels greater than 80 mg/dL during the treatment period.
VH is an indicator of average urea levels over the lifetime of Hb, while serum urea gives the renal status at the moment the sample is taken.
No evidence of renal dysfunction was indicated by elevated creatinine or urea levels (p = 0.5 creatinine, p = 0.8 urea, BD vs control animals at 24 h).
Urea levels were within the normal range and were not significantly different from control.
Blood urea levels increased only moderately during therapy, and this is consistent with increased urinary urea excretion, ultimately resulting in effective osmotic water excretion.
Urea levels were measured by urease method.
Urea levels were considered elevated if the blood urea nitrogen was >7.9 mmol/L[ 8].
This indicates that iontophoretically extracted urea can track rapid changes in plasma urea levels.
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