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Since the maximum tumour uptake of 177Lu-DOTA-chCE7 177Lu-DOTA-chCE7 177Lu-DOTA-chCE7jectisn of reachedv)., PTX wat administered 248h postoRIT in order to synchronise the maximum tumour uptake of the radiolabeled mAb and PTX-induced cell cycle arrest in the G2/M phase.
These constructs showed a rapid elimination phase compared to wild-type IgG1, more rapid tumour targeting with the maximum tumour uptake observed at an earlier time point but strongly reduced maximal tumour uptake [12 14].
111In-labelled I253A and H435A showed similar slow kinetics (t 1/2β, 63.2 and 62.2 h, respectively) and a maximum tumour uptake of 33.11 ± 4.05 and 33.69 ± 3.77 percentage injected dose per gramme (%ID/g), respectively.
Standardised uptake values (SUVs) were calculated from an oval region of interest (ROI) measuring 1.5 cm which was placed in the transaxial slice having the maximum tumour uptake on PET or PET/CT images.
Maximum tumour uptake for the whole MAbs OC125, OV-TL 3, 139H2 and a control MAb 2C7 was 8.5%, 17.7%, 11.1% and 2.5% of the injected dose g-1, reached at 72 h after injection.
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In the 4Davg data, we measured maximum tumour standardised uptake value (SUV max in the tumour, SUVmean in a lung volume of interest (VOI) and average SUV (SUVmean) in a muscle VOI.
The maximum tumour standardized uptake value (SUVmax) was derived by drawing a region of interest (ROI) encompassing the primary tumour, which defined the gross tumour volume (GTV) on PET.
Quantitative assessment of tumour and measurable normal tissue uptake of antibody by SPECT at each imaging time is shown in Figure 4. I-hDFM localised to the tumour within 2 h of injection (median 4.0% i.a. kg−1) and tumour uptake reached a maximum median level of 4.1% i.a.a
The tumour uptake of radiotracer reached a maximum of 15.0% ± 0.69% ID/g at 48 h after injection and remained high for an extended period of time (12.6% ± 1.6% ID/g at 144 h after injection).
Interestingly, this patient with grade 3 clinical flare reaction showed highest tumour uptake of F-FES (median SUVmax 15.5, maximum SUVmax 24.3).
Since the receptor-mediated tumour uptake of radiolabelled PP-F11 shows a saturable relation with peptide mass, the maximum achievable specific activity is an important parameter in this respect.
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maximum tumour growth
maximum tumour loading
maximum tumour voxel
maximum tumour volume
maximum tumour diameter
maximum phenol uptake
maximum tumor uptake
maximum blood uptake
maximum oxygen uptake
maximum tumour reduction
maximum glucose uptake
maximum tumour height
maximum tumour thickness
maximum tumour response
maximum tumour size
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