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The ideal treatment regimen should cause good symptom control through maximum tumour regression with a prolonged progression-free interval and minimal toxicity.
Measurement of circulating oestradiol levels in groups in which maximum tumour regression was observed showed no statistically significant difference when compared to the control group.
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Tumour regression occurred with both anti-oestrogens, although maximum regression was observed following oestradiol withdrawal alone.
The change in mean maximum standardised uptake value (SUV) and volume of metabolically active tissue (MTV) was compared with the tumour regression grade (TRG) in the final histology.
Pathological tumour regression grade was scored using American Joint Committee on Cancer AJCCC) 7.0.
Maximum tumour diameters were measured for each primary lung tumour volume.
For all patients, most PET-based tumour delineation methods could measure the maximum tumour diameter with moderate accuracy.
In mice treated with TMZ, the tumour volumes increased until day 9 reaching maximum tumour sizes, after which decrease of tumour sizes was observed.
TAE is a minimally invasive procedure that induces tumour regression blocking the blood flow by injection of microparticles.
An abscopal response describes radiotherapy-induced immune-mediated tumour regression at sites distant to the irradiated field.
Twelve of the 48 treated patients benefited from > 25% tumour regression, and 8 of the 48 patients had a tumour response lasting for more than 12 months.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com