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Retrospective data support a survival benefit to maximum tumour reduction in advanced stage ovarian cancer.
Three patients underwent secondary tumour resection in an attempt to achieve a maximum tumour reduction.
The comparisons of mean maximum tumour reduction in patients with Cτ above and below each decile concentration at week 4 are presented in Table 2.
The week 4 Cτ of 20.5 μg ml−1 was the greatest value that significantly discriminated median PFS and mean maximum tumour reduction.
The greatest difference in the mean maximum tumour reduction was observed at the week 4 plasma pazopanib Cτ of 20.5 μg ml−1.
Data from patients with week 4 Cτ values below the threshold selected based on differences in PFS or mean maximum tumour reduction were removed.
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The maximum percentage of tumour reduction from baseline is shown for parts 2 and 3 combined in Figure 3.
Those with a maximum partial response (>50% tumour reduction) received two further courses from maximal partial response or a total of eight cycles (whichever was the least).
This simple measurement is relatively reproducible and reduction in the maximum tumour diameter by 30% or more following therapy is taken as a sign of effective treatment.
In mice treated with TMZ, the tumour volumes increased until day 9 reaching maximum tumour sizes, after which decrease of tumour sizes was observed.
Greater than 30% reduction (partial response) in maximum tumour thickness was seen in 4 /10 (40%) following short course and 5 /9 (56%) following long course RT.
More suggestions(15)
maximum volume reduction
maximum latency reduction
maximum tumour growth
maximum tumour dose
maximum tumour loading
maximum tumour voxel
maximum velocity reduction
maximum tumour diameter
maximum pain reduction
maximum locomotor reduction
maximum tumour height
maximum tumour thickness
maximum surge reduction
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maximum tumour size
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