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This was done in order to produce a plasma peak at the time of maximum tumour loading.
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The choice of site for solid tumours will influence the maximum acceptable tumour load and the appropriate humane endpoints.
Maximum tumour diameters were measured for each primary lung tumour volume.
In mice treated with TMZ, the tumour volumes increased until day 9 reaching maximum tumour sizes, after which decrease of tumour sizes was observed.
For all patients, most PET-based tumour delineation methods could measure the maximum tumour diameter with moderate accuracy.
Figure 1 Mean differences between CT and PET derived maximum tumour diameters and corresponding pathology data.
For the first analysis, the measured maximum tumour diameters were compared with the maximum diameter obtained from pathology.
Therefore, only a comparison with maximum tumour diameter was made rather than with volume.
Maximum tumour diameter was 3.25 (1.5 16) cm.
Tumour stage and maximum tumour diameter had been assessed macroscopically in most tumours.
'Primary dimension' refers to the maximum tumour diameter (cm).
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