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Mathematically, a logistic function with very large maximum tumor volume almost equals the exponential curve.
The panel did not agree on a maximum tumor volume beyond which focal therapy is deemed not suitable.
In addition to the chosen model, model fits for several alternative choices of maximum tumor volume were evaluated, with moderate effects on the estimated values.
In vivo analysis of 66c14 luc3 cells demonstrated a small reduction in maximum tumor volume compared to parental 66c14 cells but did not produce bioluminescence in vivo.
Tumor size was gauged by caliper measurements three times per week, up to a maximum tumor volume of ∽1000 mm (tumor volume = width × length × π/6).
Several alternative levels of maximum tumor volume were therefore tested, giving weaker model fit as the maximum tumor volumes increased, thereby strengthening our assumption of a bounded growth function (rather than an exponential growth function).
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The system provides both morphologic and kinetic features of the breast lesion, and also provides quantitative information, such as, lesion dimensions and maximum tumor volumes.
Such a model can then lead to an optimal management of the available drug kinetics in order to effectively eradicate the maximum possible tumor volume while limiting toxicity of the normal cell population and that will be maintained within certain defined limits.
A multivariate analysis according to margin dose and adjusted for maximum dose, tumor volume, and volume of normal brain receiving >12 Gy confirmed a significantly longer survival in the 12 Gy group (P < 0.02).
The maximum tumor diameter and tumor volume were calculated at two points, using images yielded by the same diagnostic modality.
The propensity score was calculated by performing a binary logistic regression based on liver function and tumor characteristics, which included Child Pugh class, ascites, tumor type, maximum tumor size (>5 cm), tumor volume (>50%), number of tumors (>3), EHS and PVI.
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