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Early tumor shrinkage was defined as ≥20% decrease in the maximum tumor dimension by RECIST criteria at the time of first evaluation of response 26.
18 To ensure uniform coverage of microscopic residual disease, the IOERT applicator should have a circumferential dimension at least 1.5 to 2 cm larger than the maximum tumor dimension.
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We questioned how accurately primary tumor and suspect cervical lymph node (LN) volumes can be approximated by the maximum tumor diameters in three dimensions.
The system provides both morphologic and kinetic features of the breast lesion, and also provides quantitative information, such as, lesion dimensions and maximum tumor volumes.
Measurements were stopped when one mouse in the cage reached maximum tumor size (> 1 cm in one of its dimensions) and had to be euthanized.
Tumor size was obtained from the maximum tumor extent reported on pathology.
Clinical response measured as a reduction in tumor dimension reflects a decrease in tumor cell number.
Five weeks after tumor challenge, the largest tumor dimension was measured and the mice were killed.
Maximum tumor burden was recorded as 200 metastases.
We included patients whose maximum tumor size was ≤ 4 cm.
Maximum tumor shrinkage was correlated with increased SDF1α levels.
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