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Median time between the procedure and the maximum treatment response recorded by RECIST was 6 weeks (range, 6 12).
The effect of treatment on cough frequency continued for treatment visit 4 (maximum treatment response) and was sustained at the post treatment visit.
These results indicate that the improvement in cough reflex sensitivity occurred after the first treatment visit, increased at subsequent treatment visits (significant treatment response attained after 2 treatments and maximum treatment response after 4 treatments) and that the effect was sustained at the post treatment visit.
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In the analysis of treatment response we used a maximum of 10% in FDR as cutoff and in the analysis of survival we used a maximum of 50% in FDR as cutoff.
This delivery strategy has several advantages over the conventional maximum tolerated dose approach, apart from reduced toxicity, in that a treatment response should occur irrespective of the resistance profile of the tumour cell population.
FDG PET/CT can also be used to monitor treatment response, with multiple studies demonstrating a reduction in FDG uptake and maximum SUV after appropriate corticosteroid treatment [33, 36].
Efficacy endpoints included Treatment Outcome Score (TOS, maximum score = 100; minimally important difference = 30), a point-in-time measure of treatment response, and time to treatment response.
Patients were seen at 4-weekly intervals and the MTX dose was escalated according to treatment response at a conservative rate by 5 mg at each visit to a maximum of 25 mg weekly.
A decrease in the maximum standard glucose uptake value – SUV max, most commonly used quantitative parameter, has been associated with treatment response to numerous anticancer therapies (Shankar et al, 2006).
The maximum standardised uptake value (SUVmax) has been the most commonly used PET metabolic parameter for staging and monitoring of treatment response.
Treatment response.
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