Maximum total protein exposure was 3.5 6 times greater in the Fab group than that in either of the F ab' 2 groups.
18 According to a review of the clinical pharmacokinetics and pharmacodynamics of insulin glulisine, 12 dose proportionality in early, maximum and total exposure is observed for insulin glulisine over the therapeutic relevant dose range up to 0.4 U/kg.
In comparison, the "maximum" total front-page exposure, as measured using the high-profile Virginia Tech story, was 99.3% of ranked newspaper titles, with a cumulative print circulation of 99.8% of ranked newspapers.
Higher doses of oseltamivir (150 mg) resulted in an expected increase in the maximum concentration and total exposure of both oseltamivir and oseltamivir carboxylate (Table 3 and Fig. 2).
Chloroquine also inhibits CYP2D6 activity, although as with pyronaridine the relatively greater effect on maximum concentrations than on total exposure or elimination rate suggests that the contraction in the volume of distribution is the main cause of the higher plasma primaquine concentrations.
However, there were no statistical differences in total exposure or maximum concentration in pregnant women compared to nonpregnant women in this study.
A regression analysis of total exposure and maximum concentrations versus estimated gestational age did not deviate from zero (P = 0.334 and P = 0.245, respectively) and suggests no significant correlation between week of gestational age and drug exposure (data not shown).
A regression analysis of total exposure and maximum concentration versus estimated gestational age did not deviate from zero (P = 0.945 and P = 0.375, respectively), which suggests no significant correlation between gestational age and drug exposure (data not shown).
A regression analysis of total exposure and maximum concentration versus estimated gestational age did not deviate from zero for artemether (P = 0.487 and P = 0.671, respectively) or dihydroartemisinin (P = 0.773 and P = 0.866, respectively), which suggests no significant correlation between gestational age and drug exposure (data not shown).
Also, the European Union (EU) requires Finnish and Swedish governmental agencies to provide dietary restrictions for Baltic herring because of levels of polychlorinated dibenzo- p-dioxins and dibenzofurans (PCDD/Fs) and PCBs that might result in exposures above maximum total weekly consumption guidelines (European Commission 2006; Kiljunen et al. 2007).
