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Applying thresholds for maximum willingness-to-pay of either €20,000 or €50,000 per QALY resulted in theoretical maximum total cost of €57.76 and €77.71 (see Figure 2).
Our study also found that vaccination of boys only became cost-effective under the conditions of both an extremely low vaccine price (NZ$1 per dose) and with very low administration costs (NZ$19 per dose), up to a maximum total cost of NZ$125 per dose delivered.
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Meanwhile, the bounds for the decision variables are rigorously followed during the optimization of the objective functions (maximum effectiveness and minimum total cost), which is more realistic for an engineering design.
Then, we use spanning tree-based genetic algorithms (st-GA) by the Prüfer number representation to find the SCN to satisfy the demand imposed by customers with minimum total cost and maximum customer services for multi-objective SCN design problem of this company under condition of random fuzzy customers demand and transportation cost between facilities.
In the case where the "costs" of placing a buffer at different locations are different, we can guarantee to insert maximum number of buffers with minimum total cost.
A well-designed distribution network can help a supply chain system to achieve maximum profits or minimize total cost.
For example, the estimated time doctors spent in treating cases of incomplete abortion, when set at the minimum and maximum values, changed the total cost of PAC by only ∼$0.03 million ($30 000) above or below the mean value.
The maximum customer satisfaction and minimum total cost of the product are assumed as goals in the model.
Their model minimizes the expected total cost including maximum tardiness cost among all parts, the cost of sub-contracting for exceptional elements, and the cost of resource underutilization.
Maximum customer satisfaction and minimum total cost of the product are the objectives considered in case (1) and case (2), respectively, under single-objective approach.
In this case, efficiency is higher when more features have targets met within the maximum number, total extent or total cost of conservation areas (Camm et al., 1996; Csuti et al., 1997; Pressey et al., 1997; Cameron, Williams & Mitchell, 2008).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com