Sentence examples for maximum tolerated dosage from inspiring English sources

Compounds such as 5-benzylacyclouridine (BAU) [11] have been tested for their ability to increase the maximum tolerated dosage and therapeutic index of 5-FU through this uridine-mediated cyto-protective phenomenon [12].

Thus, the maximum tolerated dosage has been reached, and the next lower dose – taxotere 75 mg/m2 and epirubicin 105 mg/m2 – will be used for further testing.

Patients who did not achieve the target with the maximum tolerated dosage of MTX started anti-TNF therapy in association with the ongoing medication, if not contraindicated.

Immediately following the double-blind phase of the study, open-label rivastigmine was flexibly titrated over a 12-week time period to a maximum tolerated dosage of up to 6 mg BID.

Backonja et al. investigated the effect of gabapentin monotherapy on pain associated with diabetic peripheral neuropathy by titrating from 900 to 3600 mg per day or maximum tolerated dosage or placebo [ 12].

Patients randomized to either treatment group were permitted an early escape to open-label etanercept 50 mg once weekly at week 4 if they experienced >50% increase from baseline in total back pain or the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) [ 32] despite receiving NSAIDs at the maximum tolerated dosage.

Maximum tolerated dosages for interferon-alpha 2a with zidovudine, respectively, were 4.5 million U/d with 200 mg every 4 hours or 18 million U/d with 100 mg every 4 hours.

With a standard dose of paclitaxel at 135 mg m−2, the dosage of irinotecan was escalated at four levels: 75, 100, 125 and 150 mg m−2; 125 mg m−2 was established as the maximum tolerated dose; this dosage was administered to 46 patients.

The goal of dose-finding studies is to find the highest tolerable dosage: the maximum tolerated dose (MTD) that corresponds to some given acceptable toxicity rate.

The maximum tolerated dose (MTD) was defined as the dosage of 5-FU that achieved 60% grade 3/4 toxicity.

In the phase I portion, 15 patients were treated according to an escalating dosage regimen designed to determine the maximum tolerated dose.