Sentence examples for maximum tolerated concentration from inspiring English sources

The protocol also included the determination of the maximum tolerated concentration (MTC), prior to genotoxic evaluation.

sqrd-1 acts to oxidize H2S, ultimately preventing internal H2S levels from exceeding the maximum tolerated concentration.

After 2 months of culturing, the maximum tolerated concentration of CpdA was above 0.8 μM; a clonal cell line was obtained by limiting dilution and termed R0.8.

Briefly, after the determination of maximum tolerated concentration of pyrvinium in larval zebrafish, endogenous LC3-II assays were performed at the following concentrations: NH4Cl at 100 mℳ and pyrvinium at 200 nℳ for 24 h.

The maximum tolerated concentration of 17-AAG that had a minimal effect on cell proliferation of TOV-21G was found to be 0.05 μM (Supplemental Figure 4, Supporting Information).

The maximum tolerated intraparenchymal concentration was 0.5 microg/mL and tumor necrosis was observed at this concentration.

In a previous study, the maximum tolerated plasma concentrations of ropivacaine in the arterial blood of healthy volunteers were shown to be in the microgram per milliliter range [20].

Cardiac safety assessment is not the primary objective of these early studies but as these studies often use doses up to the maximum tolerated dose (MTD) achieving plasma concentrations above those that will be seen during later stages of development, SAD and MAD studies are the ideal candidates for incorporation of early QT assessment [ 5– 8].

Their morphofunctional responses in the Fe concentration range 2 1000 maximum tolerated dose revealed no cytotoxicity.

However, it was subsequently shown that the maximum tolerated dose of pentoxifylline in patients did not produce plasma concentrations high enough to match concentrations necessary to achieve the anti-inflammatory effects seen in vitro [87].

This concentration is 50%% higher than the maximum tolerated intravenous dose of MMC (20 mg/m) because HIPEC results in decreased drug absorption from the perfusate (approx. 70%) [ 5].